Gene information
Official symbol ALOX5
Official full name arachidonate 5-lipoxygenase
Gene type protein-coding gene
Chromosome10q11.21
Alias symbol5-LOX
Gene familyArachidonate lipoxygenases
Resources
Entrez Gene 240
HGNC HGNC:435
Ensembl ENSG00000012779
Vega OTTHUMG00000018081
UCSC uc001jce.5
GO terms: 45 records
GO Description Category LogP Number of genes Detail
GO:0001936 regulation of endothelial cell proliferation GO Biological Processes -54.5504306 75 More
GO:0002523 leukocyte migration involved in inflammatory response GO Biological Processes -8.96527714 10 More
GO:0002791 regulation of peptide secretion GO Biological Processes -16.5189310 23 More
GO:0008285 negative regulation of cell population proliferation GO Biological Processes -53.5569125 147 More
GO:0010817 regulation of hormone levels GO Biological Processes -29.5190556 49 More
GO:0016491 oxidoreductase activity GO Molecular Functions -14.1519969 39 More
GO:0016525 negative regulation of angiogenesis GO Biological Processes -31.9326641 51 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030258 lipid modification GO Biological Processes -3.55367288 9 More
GO:0030278 regulation of ossification GO Biological Processes -11.2759455 26 More
GO:0030501 positive regulation of bone mineralization GO Biological Processes -4.86040077 10 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031348 negative regulation of defense response GO Biological Processes -30.3795513 65 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032787 monocarboxylic acid metabolic process GO Biological Processes -19.1871601 38 More
GO:0033500 carbohydrate homeostasis GO Biological Processes -23.7918768 50 More
GO:0042593 glucose homeostasis GO Biological Processes -23.8963802 50 More
GO:0045598 regulation of fat cell differentiation GO Biological Processes -17.6607153 22 More
GO:0045765 regulation of angiogenesis GO Biological Processes -63.6171248 109 More
GO:0045778 positive regulation of ossification GO Biological Processes -4.90193440 11 More
GO:0046883 regulation of hormone secretion GO Biological Processes -20.4338227 29 More
GO:0048471 perinuclear region of cytoplasm GO Cellular Components -8.50169248 66 More
GO:0050678 regulation of epithelial cell proliferation GO Biological Processes -51.9930445 102 More
GO:0050708 regulation of protein secretion GO Biological Processes -30.3716714 63 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050728 negative regulation of inflammatory response GO Biological Processes -31.0556128 55 More
GO:0050796 regulation of insulin secretion GO Biological Processes -13.8348879 19 More
GO:0051046 regulation of secretion GO Biological Processes -54.0079540 130 More
GO:0051223 regulation of protein transport GO Biological Processes -25.2801266 81 More
GO:0070167 regulation of biomineral tissue development GO Biological Processes -10.3239090 23 More
GO:0070201 regulation of establishment of protein localization GO Biological Processes -24.4831554 82 More
GO:0080135 regulation of cellular response to stress GO Biological Processes -19.0128542 89 More
GO:0090087 regulation of peptide transport GO Biological Processes -16.3568662 23 More
GO:0090276 regulation of peptide hormone secretion GO Biological Processes -16.6841590 23 More
GO:0110149 regulation of biomineralization GO Biological Processes -10.9748263 24 More
GO:0110151 positive regulation of biomineralization GO Biological Processes -4.74345761 11 More
GO:0120254 olefinic compound metabolic process GO Biological Processes -12.8805599 18 More
GO:1900407 regulation of cellular response to oxidative stress GO Biological Processes -21.4526227 33 More
GO:1901342 regulation of vasculature development GO Biological Processes -64.8504074 111 More
GO:1901343 negative regulation of vasculature development GO Biological Processes -32.5354692 52 More
GO:1902882 regulation of response to oxidative stress GO Biological Processes -20.0046302 33 More
GO:1903037 regulation of leukocyte cell-cell adhesion GO Biological Processes -23.2079690 66 More
GO:1903530 regulation of secretion by cell GO Biological Processes -45.6472055 114 More
GO:2000181 negative regulation of blood vessel morphogenesis GO Biological Processes -32.6997315 52 More
GO:2000377 regulation of reactive oxygen species metabolic process GO Biological Processes -19.1025541 38 More
KEGG pathways: 2 records
KEGG Description Category LogP Number of genes Detail
hsa04664 Fc epsilon RI signaling pathway KEGG Pathway -4.79120438 7 More
hsa05145 Toxoplasmosis KEGG Pathway -13.6215025 17 More
Drug-Gene interaction
view
Related drugs: 25 records
Drug name Interaction type Source PMID View
5-oxo-ete DTC 24924423 view
6bio DTC 24697244 view
acacetin DTC 24368208 view
atreleuton TdgClinicalTrialTTD view
balsalazide inhibitor TdgClinicalTrial 135974519743890 view
balsalazide disodium inhibitor ChemblInteractions view
chembl416038 DTC 24231650 view
chembl502496 DTC 24231650 view
darbufelone TTD view
diethylcarbamazine inhibitor TTD 86063971886988300450114000621175235210518442 view
licofelone TdgClinicalTrial 1701564011752352 view
meclofenamate sodium inhibitor ChemblInteractions view
melatonin NCI 10668425 view
mesalamine inhibitor TdgClinicalTrialChemblInteractions 642891428829656131674 view
methotrexate NCI 8151588 view
montelukast other/unknown PharmGKB 15474500 view
olsalazine sodium inhibitor ChemblInteractions view
pf-4191834 inhibitor TTD view
rilopirox TTD view
silybin a TTD view
sulfasalazine inhibitor ChemblInteractions 642891428829656131674 view
tenidap TTD view
tepoxalin TTD view
tipelukast TTD view
zileuton inhibitor DTCTdgClinicalTrialChemblInteractionsNCITENDPharmGKBTTD 1152968810377029805877319645854246972441145466688265711069424411752352115610801032210117394438204368871949285225686392 view
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
ALOX5, VARIANT PROMOTER SP1 BINDING genomics myocardial infarction[diagnosis] myocardial infarction Allayee H et al. Am J Clin Nutr. 2008
NG_011437.1:g.4543T>C genomics fasting blood glucose[other] myocardial infarction Li Y et al. Lipids Health Dis. 2019
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